To get to Pakse, the easiest way is by air via Pakse International Airport. There are regular domestic flights from Vientiane and connections from regional hubs such as Bangkok. From the airport, it is just a short drive into the town centre.
It is also possible to reach Pakse overland. Roads connect the town to other parts of Laos and to Cambodia, making it straightforward to combine with journeys through southern Laos. The Mekong river offers another route, particularly if you are visiting Si Phan Don along the way.